Aging and major diseases such as cancer and neurodegeneration are tightly linked to metabolic rewiring, genomic instability, and epigenomic dysregulation. Post-translational modifications (PTMs) of histones and non-histone proteins play a central role in transducing metabolic states into transcriptional regulation and cell fate decisions. However, how changes in the cellular metabolome actively reshape the PTM landscape and epigenetic regulation remains poorly understood.

Our laboratory integrates chemical biology and chemical proteomics to study the interface between metabolism and epigenetics. We focus on how bioactive metabolites generated by distinct metabolic states act as triggers for site-specific protein modifications, thereby rewiring downstream signaling pathways and shaping their functional consequences.